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You will need to discuss the benefits and risks of using Allopurinol while you are pregnant. A macrophage migration-inhibition test was negative in the presence of both quinidine and allopurinol. The following information includes only the average doses of allopurinol. The mechanism is unknown and pharmacokinetic studies with hydrochlorothiazide have not demonstrated any effects on the disposition of allopurinol or oxipurinol (its major metabolite). Adverse effects can be minimized by increased hydration, urine alkalinization, and the prophylactic administration of a xanthine oxidase inhibitor such as ZYLOPRIM® (allopurinol). There are no data with Augmentin and allopurinol administered concurrently.
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